structure of 1000279-69-5

4-[5-(4-Chlorophenyl)-2-Methyl-3-Propanoylpyrrol-1-yl]Benzenesulfonamide

CAS No.: 1000279-69-5 Brand: MolBest
M. Ft.: C20H19ClN2O3S Cat. No: G8806102
M. Wt.: 402.89 MDL: No record
Storage: Store in a cool,dry area.
Purity Grade Package Stock Price Quantity
98% RG 100MG In Stock 510 USD
98% RG 250MG In Stock 872 USD
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Applications of 1000279-69-5

A-867744 shows promise in various therapeutic applications due to its ability to enhance cognitive function and provide neuroprotection. Potential applications include:

  • Cognitive Enhancement: As a treatment for cognitive impairments associated with neurodegenerative diseases.
  • Neuroprotection: Protecting neurons from damage during ischemic events or neurodegenerative processes.
  • Research Tool: Serving as a valuable tool in studying nicotinic acetylcholine receptors and their role in synaptic transmission and plasticity.

Biological Activity of 1000279-69-5

The biological activity of A-867744 is characterized by its role as a positive allosteric modulator. It has been demonstrated to potentiate the effects of acetylcholine at the alpha 7 nicotinic acetylcholine receptors, leading to enhanced synaptic transmission and potential neuroprotective effects. Studies indicate that A-867744 can inhibit receptor desensitization, which is a common limitation in the therapeutic use of nicotinic agonists. This property may make it particularly useful in treating cognitive deficits associated with conditions like Alzheimer's disease and schizophrenia.

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Bulk Packaging Price Explanation of 1000279-69-5

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Purchase Instructions of 1000279-69-5

All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

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