structure of 1001412-59-4

1H-Pyrrolo[2,3-B]Pyridine-3-Sulfonyl Chloride

CAS No.: 1001412-59-4 Brand: MolBest
M. Ft.: C7H5ClN2O2S Cat. No: G1251490
M. Wt.: 216.65 MDL: MFCD12402502
Storage: -20°C
Purity Grade Package Stock Price Quantity
98% RG 100MG In Stock 92 USD
98% RG 250MG In Stock 183 USD
98% RG 1G In Stock 469 USD
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Applications of 1001412-59-4

This compound has several applications in medicinal chemistry and biochemistry:

  • Drug Development: Due to its ability to inhibit specific enzymes and cellular processes, it serves as a lead compound for developing new anticancer agents.
  • Biochemical Research: It is utilized in proteomics research for studying protein interactions and enzyme functions.
  • Synthetic Chemistry: As a versatile sulfonylating agent, it is employed in various organic synthesis applications to create sulfonamide derivatives.

Biological Activity of 1001412-59-4

1H-pyrrolo[2,3-b]pyridine-3-sulfonyl chloride exhibits significant biological activity, particularly in the realm of cancer research. It has been shown to inhibit the proliferation of various cancer cell lines, including 4T1 (mouse breast cancer cells), MDA-MB-231, and MCF-7 breast cancer cells. The compound interacts with fibroblast growth factor receptors (FGFRs), demonstrating potent inhibitory activity that may contribute to its anticancer properties.

Molecular Mechanism

The mechanism of action involves binding interactions with biomolecules, specifically targeting the FGFR1 hinge region through hydrogen bonding. This interaction disrupts normal signaling pathways that promote cell proliferation and survival, leading to reduced cancer cell viability.

NMR spectrum of 1001412-59-4

Physical sample testing spectrum (NMR) of 1001412-59-4

Safety Information of 1001412-59-4

Pictograms

Signal Word

 Danger

Hazard Statements

 H302 Harmful if swallowed
H314 Causes severe skin burns and eye damage

Safety Data Sheet

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Purchase Instructions of 1001412-59-4

All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

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