Irinotecan hydrochloride

Irinotecan is predominantly used in chemotherapy regimens for:

• Colorectal Cancer: Often combined with other agents like 5-fluorouracil and leucovorin.
• Pancreatic Adenocarcinoma: Administered as part of multimodal treatment strategies.
• Other Cancers: Investigated for efficacy against lung and cervical cancers.

Irinotecan exhibits significant biological activity as an antitumor agent by inhibiting DNA topoisomerase I. This inhibition prevents the religation of single-strand breaks in DNA, leading to double-strand breaks during DNA replication. The resultant DNA damage triggers apoptosis in cancer cells, effectively halting tumor growth.

The compound's pharmacokinetics reveal that it has a large volume of distribution (approximately 400 L/m²) and is primarily bound to plasma proteins like albumin, which helps stabilize its active form.

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Our sales team will promptly prepare an accurate quotation for your bulk order and provide a comprehensive pricing proposal.

All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.