2-Phenyl-1-(pyridin-4-yl)ethanone

2-Phenyl-1-(pyridin-4-yl)ethanone finds applications in various domains:

• Pharmaceutical Development: Due to its biological activity against key kinases, it is being explored for potential therapeutic applications in cancer treatment and other diseases linked to dysregulated cell cycle progression.
• Organic Synthesis: The compound serves as an intermediate in synthesizing more complex organic molecules and pharmaceuticals.

Research indicates that 2-Phenyl-1-(pyridin-4-yl)ethanone exhibits significant biological activity, particularly as an inhibitor of cell cycle kinases CDK2 and CDK9. By inhibiting these kinases, the compound modulates critical biochemical pathways, including the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathway. This modulation results in increased expression of IKBα, which inhibits NF-kB activity, thereby impacting cellular proliferation and survival.

Additionally, this compound has been shown to act as an iron chelator, reducing the labile iron pool within cells and decreasing methemoglobin production in red blood cells.

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These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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