2-Phenylquinazolin-4-Amine

The applications of 2-phenylquinazolin-4-amine span various fields:

• Pharmaceutical Development: Its role as a scaffold for drug design makes it valuable in developing new therapeutic agents, particularly in oncology.
• Biochemical Research: The compound serves as a tool for studying biochemical pathways involving NQO1 and oxidative stress responses.

2-Phenylquinazolin-4-amine exhibits significant biological activities, particularly in the context of cancer research. It has been identified as an inducer of NAD(P)H:quinone oxidoreductase 1 (NQO1), an enzyme involved in the detoxification of reactive quinones and the protection against oxidative stress. The compound's interaction with cytochrome P450 1B1 (CYP1B1) is also noteworthy, as this enzyme is implicated in the metabolic inactivation of chemotherapeutic agents when overexpressed in tumor cells.

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