2-((1-(3-Chlorophenyl)-4-Oxo-4,5-Dihydro-1H-Pyrazolo[3,4-D]Pyrimidin-6-Yl)Thio)Propanamide

CAS No.: 1030203-81-6 Brand: MolBest

M. Ft.: C₁₄H₁₂ClN₅O₂S Cat. No: G6177346

M. Wt.: 349.8 MDL: No record

Storage: Store in a cool,dry area. Use: For laboratory research use only

Purity	Grade	Package	Stock	Price
98% Documents:COA SDS	RG	100MG	In Stock	439 USD
98% Documents:COA SDS	RG	250MG	In Stock	1009 USD
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Spectrums of 1030203-81-6

Attention:
1.The NMR spectrum displayed on the page is a pre-sale reference spectrum and may differ from that of the actual received batch.
2.The accompanying documentation will include the NMR spectrum and purity analysis data for the shipped batch.

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Pictograms
Signal Word	Warning
Hazard Statements	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Safety Data Sheet	SDS of 1030203-81-6.pdf

Operate under the ISO 9001 system

Applications of 1030203-81-6

HS38 has potential applications in various fields:

Pharmacology: As a selective inhibitor of DAPK1 and ZIPK, HS38 is being explored for its therapeutic potential in treating cardiovascular diseases, cancer, and neurodegenerative disorders.
Research: It serves as a valuable tool compound for studying the biological roles of DAPK family kinases in cellular signaling pathways.
Drug Development: Ongoing research aims to further optimize HS38 for increased potency and selectivity against specific kinases involved in disease processes.

Biological Activity of 1030203-81-6

The biological activity of HS38 has been demonstrated in various experimental models. Notably, it has been shown to suppress myogenic tone in rodent cerebral arteries and mitigate hypertension-related vascular responses. This suggests that HS38 may play a role in vascular smooth muscle function and could have therapeutic implications in conditions associated with abnormal vascular reactivity. Additionally, studies indicate that HS38 influences cytoskeletal dynamics and focal adhesion in vascular smooth muscle cells through DAPK3-dependent pathways.

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