1H-Pyrido[2,3-b][1,4]Oxazin-2(3H)-One(9CI)

1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one has diverse applications across various fields:

• Medicinal Chemistry: Due to its biological activity, it is being explored for its potential use in cancer therapy and other medicinal applications.
• Material Science: The compound is also utilized in developing fluorescent materials for organic light-emitting diodes (OLEDs), showcasing its versatility beyond biological applications.

Research indicates that 1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one exhibits various biological activities. Notably, it has shown potential as an anticancer agent, particularly through its ability to inhibit the proliferation of breast cancer cells in vitro. The compound acts on the Fibroblast Growth Factor Receptor (FGFR), which is involved in several critical signaling pathways related to cell growth and development. Its mode of action includes binding to fibroblast growth factors, leading to receptor dimerization and autophosphorylation of tyrosine residues, which subsequently affects cellular processes such as angiogenesis and cell migration.

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