(R,E)-Cyclooct-4-En-1-Yl (4-Nitrophenyl) Carbonate

TCO-PNB Ester has several significant applications:

• Bioconjugation: It is widely used for attaching biomolecules to surfaces or other molecules, facilitating research in proteomics and drug development.
• Targeted Protein Degradation: As a key component in PROTACs, it enables selective degradation of proteins, providing a novel approach to cancer treatment.
• Click Chemistry: Its role as a linker in click chemistry allows for rapid and efficient synthesis of complex molecules with high specificity .

The biological activity of TCO-PNB Ester is largely associated with its application in drug discovery and development. Due to its ability to form stable linkages with biomolecules, it has been employed in creating targeted therapies that can selectively degrade specific proteins within cells. This selectivity enhances therapeutic efficacy while minimizing off-target effects. Studies have shown that compounds linked through TCO-PNB Ester can effectively induce proteolysis of target proteins, showcasing its potential in cancer therapy and other diseases .

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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

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