1,2,3,4-Tetrahydro-9H-Pyrido[3,4-B]Indole

Tryptoline and its derivatives have several applications in pharmacology and medicinal chemistry:

• Antidepressant Effects: Due to its action on monoamine oxidase and neurotransmitter reuptake, tryptoline shows promise in treating depression and anxiety disorders.
• Cancer Research: Some derivatives exhibit cytotoxic properties against cancer cell lines, suggesting potential roles in cancer therapeutics.
• Neuroprotective Agents: The antioxidant properties of tryptoline derivatives may offer protective effects against neurodegenerative diseases.

Tryptoline exhibits significant biological activity, particularly as an inhibitor of monoamine oxidase type A. Its derivatives, such as 5-hydroxytryptoline and 5-methoxytryptoline (pinoline), have shown potent inhibitory effects with IC50 values of 0.5 μM and 1.5 μM, respectively. Furthermore, tryptoline acts as a reuptake inhibitor for serotonin and epinephrine, demonstrating a higher selectivity for serotonin. This activity suggests potential applications in treating mood disorders and other psychiatric conditions.

Please email your required order quantity and detailed technical specifications to sales@.
Our sales team will promptly prepare an accurate quotation for your bulk order and provide a comprehensive pricing proposal.

All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.