2-Amino-3,3,3-Trifluoropropanoic Acid

3,3,3-Trifluoro-DL-alanine is utilized in several applications:

• Imaging Tracer: Its incorporation into bacterial cell walls makes it valuable as a PET imaging tracer for detecting bacterial infections.
• Research Tool: The compound serves as a tool in biochemical research to study amino acid metabolism and bacterial physiology.
• Synthetic Intermediate: It is used as an intermediate in organic synthesis to create fluorinated compounds with potential pharmaceutical applications.

The biological activity of 3,3,3-Trifluoro-DL-alanine has been explored primarily in relation to its incorporation into bacterial peptidoglycan. Studies have shown that this compound can be effectively incorporated into the cell walls of Gram-negative bacteria like Escherichia coli, making it a potential tracer for imaging bacterial infections using positron emission tomography (PET) techniques. Its stability in serum and low substrate activity for mammalian d-amino acid oxidase suggest it may have limited toxicity and potential therapeutic applications.

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