structure of 177036-94-1

Ambrisentan,2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid(CAS 177036-94-1)

CAS No.: 177036-94-1 Brand: MolBest
M. Ft.: C22H22N2O4 Cat. No: G7980565
M. Wt.: 378.42 MDL: No record
Storage: 2-8°C Use: For laboratory research use only
HS CODE: 2933599090
Purity Grade Package Stock Price Quantity
98%
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RG 100MG In Stock 10 USD
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RG 250MG In Stock 13 USD
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RG 1G In Stock 37 USD
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RG 25G In Stock 1025 USD
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Applications of 177036-94-1

Ambrisentan is primarily indicated for:

  • Pulmonary Arterial Hypertension: It is used to improve exercise capacity and delay clinical worsening in patients classified under World Health Organization group 1.
  • Combination Therapy: It has been studied in combination with other therapies like phosphodiesterase type 5 inhibitors (e.g., tadalafil) for enhanced efficacy.

Physical and chemical properties of 177036-94-1

Acidity coefficient

0.97±0.10(Predicted)

Boiling Point

551.1ºC at 760mmHg

Density

1.228g/cm3

Exact Mass

378.15800

Flash Point

287.1ºC

Index of Refraction

1.593

LogP

3.51560

Melting Point

165-168 °C

Merck

14,384

Molecular Formula

C22H22N2O4

Molecular Weight

378.42100

PSA

81.54000

Solubility

Ambrisentan is practically insoluble in aqueous solutions at low pH. Solubility increases at higher pH.

Storage condition

-20°C Freezer

Vapour Pressure

5.56E-13mmHg at 25°C

Spectrums of 177036-94-1

Attention:
1.The NMR spectrum displayed on the page is a pre-sale reference spectrum and may differ from that of the actual received batch.
2.The accompanying documentation will include the NMR spectrum and purity analysis data for the shipped batch.
Physical sample testing spectrum (NMR) of 177036-94-1

Retrosynthesis analysis of 177036-94-1

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Download SDS of 177036-94-1

Pictograms

Signal Word

Danger

Hazard Statements

H351 Suspected of causing cancer
H360FD May damage fertility; May damage the unborn child
H361 Suspected of damaging fertility or the unborn child
H372 Causes damage to organs through prolonged or repeated exposure

Safety Data Sheet

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