Tert-Butyldimethylchlorosilane(CAS 18162-48-6)
UN No.:
UN 2921 8 /PG II
| Purity | Grade | Package | Stock | Price | Quantity |
| 98% | RG | 25G | In Stock | 2 USD
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| 98% | RG | 100G | In Stock | 3 USD
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| 98% | RG | 5G | In Stock | 3 USD
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| 98% | RG | 500G | In Stock | 8 USD
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| 98% | RG | 2.5KG | In Stock | 72 USD
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| 98% | RG | 10KG | In Stock | 244 USD
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Applications of 18162-48-6
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Protects functional groups such as hydroxyl (–OH) and amino (–NH₂) groups to enhance reaction selectivity and yield | Reacted with alcohols or amines in inert solvents (e.g., THF, DMF) at 0–25 °C to form corresponding silyl ethers or silylamines; deprotection performed subsequently under fluoride (e.g., TBAF) or acidic conditions |
| Organic Synthesis | Serves as a temporary chiral protecting group for multistep construction of complex molecules | Reacted with sensitive substrates (e.g., carbohydrates, nucleosides, peptides) under anhydrous, oxygen-free conditions at low temperature (−78 °C to 0 °C) to achieve regioselective protection |
| Materials Science | Modifies silica surfaces to prepare hydrophobic stationary phases (e.g., HPLC column packing materials) | Activated silica gel is refluxed with TBDMSCl in toluene or hexane to introduce the tert-butyldimethylsilyl group, thereby reducing surface polarity |
| Analytical Chemistry | Derivatization reagent to improve detection sensitivity and peak shape in gas chromatography (GC) or liquid chromatography (LC) for polar compounds such as alcohols, phenols, and carboxylic acids | Derivatization carried out at 60–80 °C for 30–120 min under pyridine catalysis to generate volatile and thermally stable silylated products |
| Agrochemical R&D | Protects hydroxyl groups in active molecules to improve lipophilicity and membrane permeability | Silylation of hydroxyl-containing intermediates prior to condensation reactions to optimize yield and purity in subsequent steps such as chlorination or acylation |
Physical and chemical properties of 18162-48-6
Boiling Point |
125.0±0.0 °C at 760 mmHg |
|---|---|
BRN |
505999 |
Density |
0.9±0.1 g/cm3 |
Exact Mass |
150.063156 |
Exposure Limits |
ACGIH: TWA 20 ppm OSHA: Ceiling 300 ppm; TWA 200 ppm NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3) |
Flash Point |
22.8±0.0 °C |
Index of Refraction |
1.411 |
LogP |
3.40 |
Melting Point |
86-89 °C |
Molecular Formula |
C6H15ClSi |
Molecular Weight |
150.722 |
Sensitivity |
Moisture Sensitive |
Solubility |
0.970g/L at 20°C in Water |
Storage condition |
Store at 5°C |
Vapour Pressure |
15.0±0.2 mmHg at 25°C |
Water Solubility |
Soluble in chloroform and ethyl acetate. Insoluble in water. |
Spectrums of 18162-48-6
1.The NMR spectrum displayed on the page is a pre-sale reference spectrum and may differ from that of the actual received batch.
2.The accompanying documentation will include the NMR spectrum and purity analysis data for the shipped batch.
Retrosynthesis analysis of 18162-48-6
Cas:75-78-5
Cas:594-19-4
Cas:507-20-0
Q&A for CAS 18162-48-6
1. How can I verify product quality?
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Yes. Batch COA available matches the actual shipment. COAs shown online are for reference or from previous batches.
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Download SDS of 18162-48-6
Pictograms |
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|---|---|
Signal Word |
Danger |
Hazard Statements |
H228 Flammable solid H314 Causes severe skin burns and eye damage H318 Causes serious eye damage H335 May cause respiratory irritation H411 Toxic to aquatic life with long lasting effects |
Safety Data Sheet |
Download COA of 18162-48-6
Operate under the ISO 9001 system
