structure of 204251-24-1

N-(9-Fmoc)-L-glutamic acid γ-tert-butyl ester monohydrate(CAS 204251-24-1)

CAS No.: 204251-24-1 Brand: MolBest
M. Ft.: C24H29NO7 Cat. No: G5474336
M. Wt.: 443.49 MDL: MFCD00150485
Storage: 2-8°C Use: For laboratory research use only
Purity Grade Package Stock Price Quantity
98%
Documents:COANMRLCMSSDS
RG 5G In Stock 3 USD
98%
Documents:COANMRLCMSSDS
RG 25G In Stock 9 USD
98%
Documents:COANMRLCMSSDS
RG 100G In Stock 32 USD
98%
Documents:COANMRLCMSSDS
RG 500G In Stock 120 USD
98%
Documents:COANMRLCMSSDS
RG 2.5KG In Stock 1125 USD
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Applications of 204251-24-1

Industry Application Process
Biopharmaceuticals Protecting reagent for the glutamic acid side chain in solid-phase peptide synthesis Used in Fmoc-based solid-phase peptide synthesis (SPPS) to selectively protect the γ-carboxyl group of L-glutamic acid, preventing side reactions during backbone coupling; the free glutamic acid residue is liberated upon cleavage of the tert-butyl ester with TFA and removal of the Fmoc group with piperidine
Pharmaceutical R&D Key building block for peptide therapeutics and intermediates (e.g., GLP-1 analogues, antimicrobial peptides) Employed as a chiral, orthogonally protected glutamic acid derivative in stepwise coupling or fragment condensation processes to maintain stereochemical integrity and ensure compatibility with side-chain functional groups
Fine Chemicals Standard protected amino acid raw material for high-purity custom peptide synthesis services Compatible with automated peptide synthesizers (e.g., Cyclone, Syro II), enabling amide bond formation in DMF/NMP solvents using activators such as HBTU, HATU, or DIC

Physical and chemical properties of 204251-24-1

Boiling Point

633.5ºC at 760mmHg

Exact Mass

443.194397

Flash Point

336.9ºC

H Bond Acceptors

4

H Bond Donors

2

LogP

4.42680

Melting Point

89-93ºC

Molecular Formula

C24H29NO7

Molecular Weight

443.490

optical activity

[α]20/D 17.5°, c = 1 in DMF

PSA

111.16000

Storage condition

-20°C

Vapour Pressure

6.39E-17mmHg at 25°C

Spectrums of 204251-24-1

Attention:
1.The NMR spectrum displayed on the page is a pre-sale reference spectrum and may differ from that of the actual received batch.
2.The accompanying documentation will include the NMR spectrum and purity analysis data for the shipped batch.
Physical sample testing spectrum (NMR) of 204251-24-1

Retrosynthesis analysis of 204251-24-1

Q&A for CAS 204251-24-1

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Download SDS of 204251-24-1

Pictograms

Signal Word

Warning

Hazard Statements

H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Safety Data Sheet

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