structure of 2244-11-3

Alloxan Monohydrate

CAS No.: 2244-11-3 Brand: MolBest
M. Ft.: C4H4N2O5 Cat. No: G4691274
M. Wt.: 160.08 MDL: MFCD00006031
Storage: 2-8°C
Purity Grade Package Stock Price Quantity
98% RG 100G In Stock 121 USD
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Applications of 2244-11-3

The applications of alloxan monohydrate are diverse:

  • Research Models: It is primarily utilized in experimental models for diabetes research, allowing scientists to study the disease's mechanisms and potential treatments.
  • Dye Production: Alloxan serves as a precursor for producing the purple dye murexide, which has historical significance in chemistry and dye manufacturing.
  • Pharmaceutical Research: Due to its biological activity, alloxan is also explored for potential therapeutic applications related to oxidative stress and cellular damage.

Biological Activity of 2244-11-3

Alloxan monohydrate exhibits notable biological activities:

  • Diabetes Induction: It is widely used in laboratory settings to induce diabetes in animal models due to its selective toxicity towards pancreatic beta cells. This occurs through the uptake of alloxan via the GLUT2 glucose transporter, which preferentially accumulates in these cells.
  • Oxidative Stress: The generation of ROS from alloxan contributes to oxidative stress, leading to cellular damage and apoptosis in beta cells. This mechanism is crucial for studying insulin-dependent diabetes mellitus.
  • Cytotoxicity: Alloxan's ability to cause oxidative base damage makes it a potent cytotoxic agent, influencing various cellular pathways and functions.

Safety Information of 2244-11-3

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Warning

Hazard Statements

H302 Harmful if swallowed
H312 Harmful in contact with skin
H332 Harmful if inhaled

Safety Data Sheet

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Purchase Instructions of 2244-11-3

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