structure of 253-82-7

Quinazoline

CAS No.: 253-82-7 Brand: MolBest
M. Ft.: C8H6N2 Cat. No: G2191409
M. Wt.: 130.15 MDL: MFCD00006712
Storage: Store in a cool,dry area.
Purity Grade Package Stock Price Quantity
98% RG 100G In Stock 359 USD
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Applications of 253-82-7

Quinazoline and its derivatives are widely used in pharmaceuticals due to their biological activities. They are primarily utilized in:

  • Cancer Treatment: Various quinazoline derivatives serve as targeted therapies against different cancer types.
  • Antimicrobial Agents: Some derivatives exhibit antibacterial and antifungal properties.
  • Antihypertensive Drugs: Certain compounds have been investigated for their potential use in managing high blood pressure.

Biological Activity of 253-82-7

Quinazoline derivatives exhibit notable biological activities. For instance:

  • Gefitinib: Approved by the U.S. Food and Drug Administration in 2003, this compound acts as an inhibitor of the epidermal growth factor receptor (EGFR), targeting non-small-cell lung carcinoma.
  • Afatinib: This irreversible inhibitor of HER2 and EGFR kinases was approved in 2013 and demonstrates efficacy against cancers resistant to other treatments like gefitinib and erlotinib.
  • Other derivatives have shown potential in treating conditions such as hypertension and inflammation due to their ability to inhibit various enzymes and receptors.

NMR spectrum of 253-82-7

Physical sample testing spectrum (NMR) of 253-82-7

Safety Information of 253-82-7

Pictograms

Signal Word

Warning

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Safety Data Sheet

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Bulk Packaging Price Explanation of 253-82-7

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Purchase Instructions of 253-82-7

All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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