Nutlin-3

Nutlin-3 is primarily investigated for its potential use in cancer therapy due to its ability to activate the p53 pathway. Clinical trials have explored its efficacy in various malignancies, including leukemia, prostate cancer, and solid tumors expressing wild-type p53. Furthermore, it has been studied for use in combination therapies to enhance the effects of radiation and other chemotherapeutic agents.

Nutlin-3 has demonstrated significant biological activity in various cancer models. It selectively enhances the apoptotic response in cells expressing wild-type p53 while having minimal effects on cells with mutant p53. Studies show that Nutlin-3 can sensitize cancer cells to other therapeutic agents, such as recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL), by increasing the expression of pro-apoptotic factors like DR5. Additionally, Nutlin-3 has been shown to induce acetylation of p53 and heat shock proteins, further modulating its activity and sensitivity in different cancer types.

Please email your required order quantity and detailed technical specifications to sales@.
Our sales team will promptly prepare an accurate quotation for your bulk order and provide a comprehensive pricing proposal.

All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.