2-Amino-9-Methyl-1H-Purin-6(9H)-One

9-Methylguanine has several applications in research and medicine:

• Cancer Research: Its role as a mutagenic agent makes it significant in studies related to cancer development.
• Biochemical Studies: Used as a model compound to study DNA repair mechanisms and oxidative stress.
• Pharmaceutical Development: Investigated for potential use in developing drugs targeting DNA repair pathways.

Biologically, 9-methylguanine is recognized for its role as a DNA lesion. It can interfere with normal base pairing during DNA replication, leading to mutations. The enzyme O6-methylguanine-methyltransferase is responsible for repairing this lesion by transferring the methyl group from the guanine base to a cysteine residue in the enzyme, effectively reversing the damage. This repair mechanism is vital for maintaining genomic stability.

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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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