structure of 578-76-7

7-Methylguanine

CAS No.: 578-76-7 Brand: MolBest
M. Ft.: C6H7N5O Cat. No: G5017479
M. Wt.: 165.15 MDL: No record
Storage: Store in a cool,dry area.
Purity Grade Package Stock Price Quantity
95% RG 100MG In Stock 30 USD
95% RG 250MG In Stock 42 USD
95% RG 1G In Stock 74 USD
95% RG 5G In Stock 355 USD
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Applications of 578-76-7

The applications of 7-methylguanine are diverse:

  • Pharmaceutical Development: As a potential anticancer agent due to its ability to inhibit DNA repair mechanisms.
  • Biomarker Research: Its presence in biological fluids may serve as a biomarker for certain diseases or dietary habits.
  • Molecular Biology: Used in studies involving RNA modifications and interactions with other biomolecules.

Biological Activity of 578-76-7

7-Methylguanine exhibits significant biological activity, particularly as an inhibitor of poly(ADP-ribose) polymerase 1 (PARP-1) and other DNA repair enzymes. By competitively inhibiting these enzymes, it can enhance the effectiveness of certain chemotherapeutic agents like cisplatin and doxorubicin, leading to increased apoptotic death in cancer cells. Moreover, it does not induce mutations or chromosomal abnormalities, suggesting a relatively safe profile for potential therapeutic applications.

NMR spectrum of 578-76-7

Physical sample testing spectrum (NMR) of 578-76-7

Safety Information of 578-76-7

Pictograms

Signal Word

Warning

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Safety Data Sheet

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Purchase Instructions of 578-76-7

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