1-Methylimidazole-2-thiol

Methimazole exhibits significant biological activity by effectively lowering levels of thyroid hormones in patients with hyperthyroidism. Its onset of action typically occurs within 12 to 18 hours after administration, making it a rapid therapeutic option for managing elevated thyroid hormone levels. Methimazole is approximately ten times more potent than propylthiouracil and has a longer duration of action.

The drug is primarily absorbed from the gastrointestinal tract, achieving peak plasma concentrations within 1 to 2 hours post-administration. Its bioavailability ranges from 80% to 95%, and it demonstrates minimal protein binding.

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