Dimethyl Fumarate

Dimethyl fumarate is primarily used in the treatment of:

• Multiple Sclerosis: Approved by the U.S. Food and Drug Administration as a disease-modifying therapy.
• Psoriasis: Used in formulations for moderate-to-severe plaque psoriasis treatment.

Its immunomodulatory effects make it a candidate for other autoimmune diseases and inflammatory conditions .

The biological activity of dimethyl fumarate is primarily attributed to its ability to modulate immune responses. It activates the Nuclear factor erythroid-derived 2-like 2 (Nrf2) pathway, which plays a significant role in cellular defense against oxidative stress. The compound has been shown to shift T helper cell profiles from pro-inflammatory (Th1/Th17) to anti-inflammatory (Th2), thereby reducing inflammatory cytokine production .

• Immunomodulation: Alters lymphocyte subpopulations and reduces central nervous system infiltration.
• Epigenetic Regulation: Influences micro-RNA expression related to autoimmune responses.

Please email your required order quantity and detailed technical specifications to sales@.
Our sales team will promptly prepare an accurate quotation for your bulk order and provide a comprehensive pricing proposal.

All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.