4-[[(4S, 5R)-4,5-Bis(4-Chlorophenyl)-4,5-Dihydro-2-[4-Methoxy-2-(1-Methylethoxy)Phenyl]-1H-Imidazol-1-Yl]Carbonyl]-2-Piperazinone
| Purity | Grade | Package | Stock | Price | Quantity |
|---|---|---|---|---|---|
| 98% | RG | 5MG | In Stock | 57 USD | |
| 98% | RG | 25MG | In Stock | 172 USD | |
| 98% | RG | 100MG | In Stock | 271 USD | |
| 98% | RG | 250MG | In Stock | 591 USD | |
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Applications of 675576-98-4
Nutlin-3A is primarily investigated for its potential in cancer therapy due to its ability to reactivate p53 signaling in tumors with MDM2 overexpression. Its applications include:
- Cancer Treatment: Particularly effective in cancers with wild-type p53, such as certain leukemias and solid tumors.
- Combination Therapies: Nutlin-3A has shown synergistic effects when combined with other chemotherapeutic agents like fludarabine.
- Research Tool: Used extensively in laboratory settings to study p53 biology and MDM2 interactions.
Biological Activity of 675576-98-4
Nutlin-3A has demonstrated significant biological activity in various cancer models. It induces apoptosis in cells expressing wild-type p53 by activating both transcription-dependent and transcription-independent pathways. In chronic lymphocytic leukemia, for instance, Nutlin-3A was shown to induce apoptosis in a majority of untreated patient samples. Additionally, it inhibits migration and invasion of cancer cells by causing cytoskeletal rearrangements, further enhancing its therapeutic potential against metastasis.
NMR spectrum of 675576-98-4
Safety Information of 675576-98-4
Download COA of 675576-98-4
Bulk Packaging Price Explanation of 675576-98-4
Please email your required order quantity and detailed technical specifications to sales@.
Our sales team will promptly prepare an accurate quotation for your bulk order and provide a comprehensive pricing proposal.
Purchase Instructions of 675576-98-4
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
