1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-5-Ethynylpyrimidine-2,4(1H,3H)-Dione

5-Ethynyluridine has several applications in biological research:

• RNA Synthesis Monitoring: It is primarily used to measure de novo RNA synthesis in proliferating cells, providing insights into transcriptional dynamics.
• Cell Imaging: The compound allows for the visualization of newly synthesized RNA using fluorescence microscopy after click chemistry labeling.
• Transcriptome Analysis: It can be utilized in various transcriptomic assays, including RNA sequencing and turnover studies.

The biological activity of 5-ethynyluridine is characterized by its ability to incorporate into nascent RNA chains during transcription. Studies have shown that it can efficiently label RNA in various cell types, making it a valuable tool for measuring transcription rates and studying RNA metabolism. Unlike some other nucleoside analogs, 5-ethynyluridine does not integrate into DNA, which helps in distinguishing between RNA and DNA synthesis in experiments.

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