4-Bromobenzenesulfonamide

4-Bromobenzenesulfonamide finds applications in several fields:

• Pharmaceuticals: It serves as a key intermediate in the synthesis of various medicinal compounds due to its biological activity.
• Organic Synthesis: Used as a reagent in the preparation of cobalt(III) complexes and other chemical transformations.
• Research: Its role as a carbonic anhydrase inhibitor makes it valuable in cancer research and drug development.

4-Bromobenzenesulfonamide exhibits significant biological activity, primarily as an inhibitor of carbonic anhydrase IX (CA IX), an enzyme overexpressed in many solid tumors. By inhibiting CA IX, this compound disrupts pH regulation within cancer cells, leading to reduced tumor growth and proliferation. The compound has shown inhibitory effects against various cancer cell lines at concentrations ranging from 1.52 to 6.31 μM. Its action is influenced by the tumor microenvironment, particularly under hypoxic conditions.

Additionally, it has been observed to induce apoptosis in cancer cells and alter cellular signaling pathways and metabolism.

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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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