(+/-)-2,2-Dibromo-1,1-Binaphthyl

2,2'-Dibromo-1,1'-binaphthyl finds applications across several fields:

• Organic Synthesis: It serves as a key intermediate in the synthesis of various biaryl compounds used in pharmaceuticals and agrochemicals.
• Chiral Ligands: The compound is utilized in asymmetric synthesis as a chiral ligand in transition metal catalysis due to its chirality and ability to form stable complexes.
• Material Science: Its unique structural properties make it suitable for applications in organic electronics and photonic materials.

Research indicates that 2,2'-dibromo-1,1'-binaphthyl exhibits significant biological activity, particularly as an inhibitor of certain cytochrome P450 enzymes. Specifically, it has been identified as an inhibitor of CYP1A2 and CYP2C19 enzymes, which are involved in drug metabolism. Its lipophilicity suggests potential interactions with biological membranes, although its low gastrointestinal absorption limits its bioavailability when administered orally.

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