structure of 77-86-1

Tris(hydroxymethyl)aminomethane(CAS 77-86-1)

CAS No.: 77-86-1 Brand: MolBest
M. Ft.: C4H11NO3 Cat. No: G7124777
M. Wt.: 121.14 MDL: MFCD00004679
Storage: Store in a cool,dry area. Use: For laboratory research use only
HS CODE: 2922199090
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99.5-100.5%,ACS
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Applications of 77-86-1

Industry Application Process
Biomedical Research Buffer component for electrophoresis, DNA/RNA extraction, PCR, and related assays Formulated into Tris-HCl buffer solutions (pH 7.0–9.0) to maintain stable pH in reaction systems
Pharmaceutical Industry pH adjuster and stabilizer in drug formulations, including injectables, ophthalmic solutions, and protein-based therapeutics Added to final sterile formulations to control pH within physiologically compatible ranges (e.g., 7.2–7.6)
Cosmetics pH adjuster and skin-conditioning agent in conditioners, shampoos, and skincare products Neutralized with acid (e.g., hydrochloric acid) prior to incorporation to ensure product pH of 4.5–6.5, supporting skin barrier function
Molecular Diagnostics Reagents Core buffering component in nucleic acid detection kits Serves as a foundational component in RT-PCR and isothermal amplification (e.g., LAMP) reaction buffers to ensure enzymatic activity and specificity
Cell Culture Supplement for pH adjustment of basal media (e.g., MEM, DMEM) Used in conjunction with CO₂ equilibrium systems to enhance pH buffering capacity, particularly under low-CO₂ or CO₂-free culture conditions

Physical and chemical properties of 77-86-1

Acidity coefficient

8.1(at 25℃)

Boiling Point

219-220 °C at 10 mm Hg

BRN

741883

Decomposition

When heated to decomposition it emits toxic fumes of /nitrogen oxide/.

Density

1.3±0.1 g/cm3

Exact Mass

121.073891

Flash Point

169.7±26.5 °C

Index of Refraction

1.544

LogP

log Kow = -1.56 (est)

Melting Point

171-172 °C

Merck

14,9772

Molecular Formula

C4H11NO3

Molecular Weight

121.135

Odor

SLIGHT, CHARACTERISTIC ODOR

pH

pH of 0.1 molar aq soln = 10.4

pH Range

7 - 9

PSA

86.71000

Sensitivity

Hygroscopic

Stability

Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.

Storage condition

2-8°C

Vapour Pressure

2.2X10-5 mm Hg at 25 °C (est)

Water Solubility

550 g/L (25 ºC)

λmax

λ: 260 nm Amax: 0.10
λ: 280 nm Amax: 0.08

Spectrums of 77-86-1

Attention:
1.The NMR spectrum displayed on the page is a pre-sale reference spectrum and may differ from that of the actual received batch.
2.The accompanying documentation will include the NMR spectrum and purity analysis data for the shipped batch.
Physical sample testing spectrum (NMR) of 77-86-1

Retrosynthesis analysis of 77-86-1


Q&A for CAS 77-86-1

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Download SDS of 77-86-1

Pictograms

Signal Word

Warning

Hazard Statements

H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation

Safety Data Sheet

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