4-Maleimidobutyric Acid N-Succinimidyl Ester(CAS 80307-12-6)
| Purity | Grade | Package | Stock | Price | Quantity |
| 98% | RG | 250MG | In Stock | 3 USD
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| 98% | RG | 1G | In Stock | 7 USD
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| 98% | RG | 5G | In Stock | 30 USD
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| 98% | RG | 25G | In Stock | 235 USD
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| 98% | RG | 100G | In Stock | 895 USD
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Quality System
Applications of 80307-12-6
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Chemical modification and crosslinking of biomacromolecules, such as proteins and peptides | In a pH 7.5–9.0 buffer system (e.g., PBS or carbonate buffer), the NHS ester group undergoes nucleophilic substitution with primary amines (e.g., lysine side chains or N-terminal amines) to form stable amide bonds, introducing maleimide functionality for subsequent thiol-specific conjugation |
| Antibody–Drug Conjugate (ADC) Development | Preparation of thiol-reactive linker intermediates to enable site-specific conjugation of antibodies to small-molecule toxins | MBSA is first coupled to antibody lysine residues via NHS ester chemistry to introduce maleimide groups; subsequently, it reacts with free thiols on toxins (generated by partial reduction) via Michael addition to form stable thioether bonds |
| Materials Science | Surface functionalization of nanoparticles, microspheres, and solid-phase carriers to confer thiol reactivity | In organic solvents (e.g., DMF or DMSO) or aqueous/organic mixed phases, MBSA reacts with amine-functionalized surfaces (e.g., amino-modified silica, amino magnetic beads, or NH₂-PEG-coated liposomes) to generate surface-bound maleimide groups, enabling subsequent conjugation of thiolated ligands (e.g., peptides or nucleic acids) |
| Diagnostics Reagents | Preparation of thiol-labeled fluorescent probes, enzyme-conjugated antibodies, and biosensor recognition elements | MBSA is reacted with amine-containing reporter molecules (e.g., FITC-NH₂ or HRP-NH₂) to yield maleimide-reporter conjugates, which are then coupled to target proteins or aptamers bearing free thiols to achieve oriented, controlled labeling |
Physical and chemical properties of 80307-12-6
Acidity coefficient |
-2.27±0.20(Predicted) |
|---|---|
Boiling Point |
461.3±47.0 °C at 760 mmHg |
BRN |
6427689 |
Density |
1.5±0.1 g/cm3 |
Exact Mass |
280.069550 |
Flash Point |
232.8±29.3 °C |
Index of Refraction |
1.595 |
LogP |
-1.56 |
Melting Point |
123-129ºC |
Molecular Formula |
C12H12N2O6 |
Molecular Weight |
280.233 |
PSA |
101.06000 |
Solubility |
chloroform: 100 mg/mL |
Stability |
Hygroscopic, Moisture Sensitive |
Storage condition |
2-8°C |
Vapour Pressure |
0.0±1.1 mmHg at 25°C |
Water Solubility |
chloroform: 100 mg/mL |
Spectrums of 80307-12-6
1.The NMR spectrum displayed on the page is a pre-sale reference spectrum and may differ from that of the actual received batch.
2.The accompanying documentation will include the NMR spectrum and purity analysis data for the shipped batch.
Retrosynthesis analysis of 80307-12-6
Cas:57078-98-5
Cas:6066-82-6
Q&A for CAS 80307-12-6
1. How can I verify product quality?
Every batch of our Chemical Reagents is tested to meet ISO 9001 standards. We provide COA & NMR & SDS Provided with each shipment. Batch COA available for verification, and third-party retesting is supported. A full refund is offered if our data is incorrect.
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Orders from Ready stock / In stock items typically Ships Tomorrow via Fast Shipping via FedEx/DHL/UPS. International deliveries usually arrive within 7 business days, subject to customs clearance.
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If your Lab Grade Chemical Reagents do not match the Batch COA available, we will issue a replacement or a full refund upon verification.
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Hazardous products are labeled and packaged following international regulations. We provide SDS Provided with all hazardous shipments to ensure safe and compliant transport.
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Yes. Our Lab Supplier team is available to assist with questions about product usage, storage, Lab Grade requirements, applications, and more.
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Yes, samples are available for selected Lab Grade products. Please submit a request to confirm availability and specifications.
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9. Can you customize purity or packaging?
Yes. We support customization of Lab Grade purity, packaging size, and special testing requirements. Share your needs and we’ll provide a tailored solution.
10. Is the COA consistent with the shipped batch?
Yes. Batch COA available matches the actual shipment. COAs shown online are for reference or from previous batches.
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Yes. We offer Lab Supplier services for stable batch consistency, pricing agreements, and safety stock for long-term customers to ensure uninterrupted supply.
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Download SDS of 80307-12-6
Pictograms |
 |
|---|---|
Signal Word |
Warning |
Hazard Statements |
H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation |
Safety Data Sheet |
Download COA of 80307-12-6
Operate under the ISO 9001 system
