1,1’-(Octanedioylbis(Oxy))Bis(2,5-Dioxopyrrolidine-3-Sulfonic Acid)

Bis(sulfosuccinimidyl)suberate has a wide range of applications in biological research:

• Cell-surface receptor-ligand studies: It facilitates the investigation of interactions between cell surface proteins.
• Crosslinking biomolecules on cells: It aids in stabilizing protein complexes prior to analysis.
• Protein interaction analysis: It is utilized for fixing protein interactions to identify weak or transient associations.
• Bioconjugation: It allows for the creation of conjugates by linking proteins to various molecules, enhancing detection and analysis capabilities.

The biological activity of bis(sulfosuccinimidyl)suberate is significant in the context of protein interaction studies. It is particularly useful for stabilizing transient or weak protein-protein interactions, allowing researchers to analyze these interactions through techniques such as immunoprecipitation and mass spectrometry. Additionally, its inability to permeate cell membranes makes it ideal for studying surface proteins without affecting intracellular processes.

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