5-Bromouridine

5-Bromouridine has several important applications in molecular biology and biochemistry:

• RNA Labeling: It is extensively used for labeling RNA during synthesis studies, enabling researchers to track RNA dynamics and degradation .
• Studying RNA Splicing: Its incorporation into pre-mRNA helps investigate the splicing mechanisms and the role of specific nucleotides in this process .
• Cancer Research: Due to its ability to induce apoptosis and affect cell cycle progression, it is being explored as a potential therapeutic agent against certain cancers .
• Detection Methods: Techniques such as flow cytometry utilize 5-bromouridine for detecting RNA synthesis at the single-cell level .

5-Bromouridine exhibits significant biological activity, particularly in the context of RNA metabolism. It has been utilized to label newly synthesized RNA molecules, allowing for the measurement of RNA production rates and half-lives through techniques such as 5'-bromo-uridine immunoprecipitation chase-deep sequencing analysis (BRIC-seq) . This method enables researchers to track RNA dynamics without significantly affecting cell viability.

Moreover, studies indicate that 5-bromouridine can inhibit splicing efficiency when incorporated into pre-mRNA transcripts, suggesting that uridines are critical for proper splicing reactions . Its ability to induce apoptosis and halt cell cycle progression at the S phase has also been documented, showcasing its potential as an anticancer agent .

Please email your required order quantity and detailed technical specifications to sales@.
Our sales team will promptly prepare an accurate quotation for your bulk order and provide a comprehensive pricing proposal.

All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.