5-Ethynyl-1-[(2R,3S,4R,5R)-3-Fluoro-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrimidine-2,4-Dione

1-(2-Deoxy-2-Fluoro-Beta-D-Arabinofuranosyl)-5-Ethynylpyrimidine-2,4(1H,3H)-Dione exhibits significant antiviral properties. Studies indicate that it has comparable efficacy to established antiviral agents like acyclovir against herpes simplex viruses. It shows lower cellular toxicity and a similar affinity for thymidine kinases encoded by both HSV types compared to traditional nucleosides.

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